A Clearinghouse for Information about Blood Clots (DVT/)PE) and Clotting Disorders (thrombophilia) provided as a public service by the University of North Carolina Blood Research Center

Category: Heparin

  • Two Things Physicians Should Avoid

    Stephan Moll, MD writes (Dec 17, 2014)…  The American Society of Hematology (ASH) published last week as part of its Choosing Wisely® campaign two things that physicians dealing with DVT, PE and anticoagulants should avoid [ref 1].

  • Argatroban Nomogram

    Stephan Moll, MD writes…. The treatment of heparin induced thrombocytopenia may require the use of argatroban. Here is the argatroban nomogram  used at our institution, the University of North Carolina (UNC) at Chapel Hill. Disclosure: I have no financial disclosures relevant to this post. Last updated: June 25th, 2013

  • LMWH Injections – Making it Easier: Insuflon Ports

    Once or twice daily injections of s.c. anticoagulants for prolonged periods of time can be bothersome and unacceptable for the patient. Use of a once weekly exchanged s.c. port, called Insuflon, can make longer-term s.c. anticoagulant therapy easier and more tolerable.

  • Pregnancy Loss and Thrombophilia

    How common is pregnancy loss? What are the causes? Pregnancy loss  in the general population is common. Most losses occur in the first trimester. As many as 5 % of women have 2 or more early losses; 1-2 % have 3 or more early losses [ref 1]. Well established risk factors for pregnancy loss are:…

  • Purple Toe Syndrome

    Warfarin can, in rare instances, cause violaceous painful discoloration of the toes and the sides of the feet, referred to as the “purple toe syndrome” 1 – see photograph below. Occasionally, the hands can also be involved and a net-like skin rash on abdomen and legs (= livedo reticularis) can occur. This typically happens within the…

  • HIT (Heparin-Induced Thrombocytopenia)

    A detailed discussion of Heparin-Induced Thrombocytopenia (HIT) written for patients is available on the Clot Connect Patient blog- connect here. We hope that the health care professional will consider this document to be suitable as an information handout to his/her patients with HIT. The discussion also contains 2 resources for use by the health care provider: