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FDA Approval of New Drug to Treat Major Bleeding on Warfarin – Kcentra
Stephan Moll, MD writes… A new drug for the urgent reversal of warfarin was approved by the FDA today, April 29th, 2013 (announcement by the FDA is here), called Kcentra. The drug is derived from pooled plasma from healthy blood donors and contains the coagulation factors that are low in warfarin-treated patients, i.e. factors II, VII,…
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Minor Cuts and Nosebleeds on Anticoagulants
When a patient on warfarin bleeds more than usual it is, of course, important to make sure that the INR is not supra-therapeutic. And, if the INR is too high, warfarin therapy needs to be adjusted and other treatment (vitamin K, etc) may have to be employed depending on the degree of INR elevation and…
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Minor Cuts and Bleeding on Blood Thinners
When a patient on warfarin bleeds more than usual it is important to make sure that the INR is not above the desired (therapeutic) range. If the INR is too high, i.e. the blood is too thin, warfarin may have to be interrupted; if it is very high vitamin K sometimes has to be given…
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Being on Blood Thinners: How Do I Know I am Bleeding?
Emily Hawes, UNC School of Pharmacy, writes… Patients on blood thinners are at increased risk for bleeding. This can be easy to recognize external bleeding (bruising, bleeding from a cut, nosebleeds, etc.) or more occult internal bleeding. Patients need to know how to recognize abnormal bleeding. If any of the below signs of abnormal bleeding occur patients need…
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Dental Work on Warfarin
A number of dental procedures can be done safely withouthaving to discontinue warfarin. A clinically helpful table is can be found here: Dental procedures and Warfarin (from ref 1).
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Pradaxa – Management of Major Bleeding
Major and life-threatening bleeding is expected to occur in some patients treated with Pradaxa® (=Dabigatran). The question will then urgently arise how to best treat such catastrophic bleeding.
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Pradaxa – Management of Major Bleeding
Major and life-threatening bleeding is expected to occur in some patients treated with Pradaxa® (=Dabigatran). The question will then urgently arise how to best treat such catastrophic bleeding. As there have been no data published on this topic in the peer-reviewed medical literature, we don’t know how to best manage a patient with major and…
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Heavy Menstrual Bleeds on Anticoagulants – Treatment Options
Evaluation Anticoagulants often increase the amount of bleeding during menses and sometimes the number of days that a woman bleeds. However, this does not happen in every woman. In general, the more vaginal bleeding a woman has, the more cramping she experiences. Since warfarin may increase the vaginal bleeding
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