A Clearinghouse for Information about Blood Clots (DVT/)PE) and Clotting Disorders (thrombophilia) provided as a public service by the University of North Carolina Blood Research Center

Category: warfarin / coumadin

  • Safe Pain Medications on Warfarin

    Certain pain medications increase the risk of bleeding in patients on warfarin (coumadin®, Jantoven).  Two mechanism can be at play: (1) non-steroidal pain medications (NSAIDs = non-steroidal anti-inflammatory drugs) may lead to gastritis which can lead to bleeding into the stomach, made worse by being on “blood thinners”, and (2) pain medications taken on a…

  • INRs that Fluctuate

    Background and summary Quite a few patients on warfarin have unstable, i.e. significantly fluctuating INRs, making warfarin therapy quite cumbersome.  The cause of such fluctuations is often not clear.  However, the following causes should be considered. Solutions how to deal with fluctuating INRs are also listed below.

  • Warfarin therapy made easier

    Background and Summary Patients on warfarin can test their own INR (International Normalized Ratio) at home with small, handheld INR monitors, similar to diabetics checking their own blood sugar. A very large, well conducted study published on Oct 21, 2010 in the New England Journal of Medicine (ref 1) shows that patients can safely and…