A Clearinghouse for Information about Blood Clots (DVT/)PE) and Clotting Disorders (thrombophilia) provided as a public service by the University of North Carolina Blood Research Center

Category: Therapy

  • Testosterone and Thrombosis

    Testosterone Replacement Therapy Replacement therapy with low doses of testosterone does not adversely affect blood coagulation status [ref 1] and does not appear to increase the risk of venous or arterial thrombosis. Thrombosis is not listed as a potential side effect in the commly used drug compendium (Micromedex). Furthermore, the 2006 “Clinical Practice Guideline” from the…

  • Testosterone and Blood Clots

    Testosterone Replacement Therapy Replacement therapy with low doses of testosterone does not adversely affect blood coagulation status [ref 1] and does not appear to increase the risk of venous or arterial blood clots. Thrombosis is not listed as a potential side effect in a commly used drug compendium (Micromedex). Furthermore, the 2006 “Clinical Practice Guideline”…

  • HHT

    What is HHT? HHT (Hereditary Hemorrhagic Teleangiectasia), called Osler-Weber-Rendu syndrome,  is an inherited disorder in which small blood vessels develop abnormally [ref 1].  It is estimated that 30,000 to 60,000 people (1 out 5,000 to 10,000) in the United States are affected. Individuals with HHT develop telengiectasias in the skin (usually in the fingers and hands) and…

  • HHT

    What is HHT? HHT (Hereditary Hemorrhagic Teleangiectasia) is an inherited disorder in which small blood vessels develop abnormally [ref 1].  It is also called Osler-Weber-Rendu syndrome. It is estimated that 30,000 to 60,000 people (1 out every 5,000 to 10,000) in the United States have it. Individuals with HHT develop small abnormal blood vessels (teleangiectasias)…

  • HIT = Heparin-induced Thrombocytopenia

    What Is HIT? Heparin-induced thrombocytopenia (HIT) is a serious side effect that may occur when you are being treated with heparin. It may lead to low blood platelet counts and to life-threatening blood clots.

  • Dental Work on Warfarin

    A number of dental procedures can be done safely withouthaving to discontinue warfarin. A clinically helpful table is can be found here: Dental procedures and Warfarin (from ref 1).

  • INRs that Fluctuate – Solutions

    Background and summary The cause  of fluctuating INRs in patients on warfarin is often not clear.  The following causes should be considered. Solutions how to deal with fluctuating INRs are listed further below.

  • Xarelto® – Good News

    Summary Good news. A major study published in December 2010 in the  New England Journal of Medicine (NEJM) shows that the new oral “blood thinner” Xarelto® (=Rivaroxaban) is (a) as safe and effective as warfarin in patients with acute DVT, and (b) is quite effective in preventing recurrent venous thromboembolism if taken longer-term, with an…