A Clearinghouse for Information about Blood Clots (DVT/)PE) and Clotting Disorders (thrombophilia) provided as a public service by the University of North Carolina Blood Research Center

Category: Thrombophilias

  • New Comprehensive Clinical Guidance on VTE Treatment

    Stephan Moll, MD writes… A new consensus guidance on management of venous thromboembolism (VTE) – link here – was published today, Jan 18th, 2016, in the Journal of Thrombosis and Thrombolysis.  The publication contains 13 chapters on various aspects of VTE

  • Thrombophilia – Information Handout for Patients

    Stephan Moll, MD writes… An information article on various aspects of thrombophilia, written for patients and family members, was published today – available here – as a Vascular Disease Patient Information Page in the journal Vascular Medicine.  It addresses (a) in which patient with venous thromboembolism to consider thrombophilia  testing, (b) what tests might be appropriate to do, (c) how the test results…

  • Three Things We Shouldn’t Do

    Stephan Moll, MD writes…  The American Society of Hematology (ASH) has identified 3 things that physicians dealing with DVT, PE and anticoagulation should avoid – published today [ref 1].

  • International Coagulation Meeting (ISTH 2013): Highlights

    Stephan Moll, MD writes…  A major international coagulation conference, the bi-annual meeting of the International Society for Thrombosis and Haemostasis (ISTH; http://www.isth.org), took place in Amsterdam, Holland, from June 29th to July 4th, 2013.  The clinically relevant highlights about thrombosis and anticoagulation are summarized below.

  • Thrombophilia Testing – Reliable on Anticoagulants?

    Stephan Moll, MD writes…  The decision how long to treat a patient with venous thromboembolism (VTE) with anticoagulants can often be made based on the patient’s history alone, i.e. the circumstances of the VTE event (provoked versus unprovoked).  Often, no thrombophilia testing is needed.  However, if one were to do thrombophilia testing, what is the…

  • Blood or Organ Donation: The Patient on Anticoagulants or with Thrombophillia

    A patient may ask:  “I am on warfarin – can I donate blood?”  Your answer:  “No”.  A person on an anticoagulant will not be accepted as a blood donor

  • Thrombophilia and Insurance

    Liz Varga, Certified Genetic Counselor, Nationwide Children’s Hospital, Columbus OH writes…. Some patients or their family members may be concerned about genetic testing for thrombophilias for fear of genetic discrimination.  Fortunately in the United States, laws are in place that can alleviate this concern. 

  • Protein C Deficiency

    Inherited protein C deficiency is considered a stronger thrombophilia. It increases the risk for venous and arterial thromboembolism, and possibly for early and late pregnancy loss and other adverse pregnancy outcomes (preeclampsia, IUGR, placental abruption).  There are 2 major causes for low protein C values: