A Clearinghouse for Information about Blood Clots (DVT/)PE) and Clotting Disorders (thrombophilia) provided as a public service by the University of North Carolina Blood Research Center

Category: Venous clots

  • New Publication: Eliquis (Apixaban) is Effective and Safe in DVT and PE

    Stephan Moll, MD writes…   An important study (AMPLIFY trial) was published today in the New England Journal of Medicine [ref 1]: In a large study of 5395 patients with acute DVT or PE, Eliquis (apixaban) was as effective as warfarin and caused less major bleeding.

  • Top 10 Publications on Thrombosis and Anticoagulation from 2012

    Stephan Moll writes… 2012 has been a year with significant progress in the field of venous thromboembolism and anticoagulation.  The three most noteworthy, clinically relevant developments were probably (a) the publication of the new ACCP (American College of Chest Physician) guidelines on antithrombotic therapy in February 2012; (b)  The FDA-approval of rivaroxaban (Xarelto) in November 2012 for the acute…

  • TTP with I.V. Use of Pain Medication OpanaER

    Stephan Moll, MD writes…  The CDC published an alert on Oct 26th, 2012, that they are investigating 12 cases of TTP (thrombotic thrombocytopenic purpura) in drug users who injected intravenously the opioid pain medication Opana ER® (oxymorphone extended-release), a medication made as a tablet and meant for oral use. The tablet was pulverized by the drug…

  • Ischemic Colitis and Thrombophilia

    Stephan Moll, MD writes…  Ischemic colitis is an uncommon and typically benign disorder.  For mostly unclear reasons, multiple small vessels in the colonic wall have decreased perfusion or become occluded, resulting in patchy, superficially ulcerated areas.  Typically, no surgical intervention is needed and the patient recovers spontaneously within 1-2 weeks.  Often patients have only one episode. Few…

  • Recovery After a DVT or PE

    Stephan Moll, MD writes…  A discussion for patients of questions commonly asked after a DVT are discussed here, in Clot Connect’s patient blog, such as: How quickly can I expect improvement? How active can I be after a DVT or PE? When can I go back to doing sports? When is it safe to fly again…

  • DVT in Young Adults – IVC Abnormalities

    Stephan Moll, MD writes….. When a young person is diagnosed with extensive pelvic DVT or inferior vena cava thrombosis, there may be an underlying and predisposing congenital abnormality of the IVC, such as a congenital absence (agenesis, aplasia) or narrowing (hypoplasia) of the IVC

  • New ACCP Guidelines – DVT and PE: Highlights and Summary

    Stephan Moll, MD writes…  This month the American College of Chest Physicians (ACCP) published its new (2012) guidelines regarding anticoagulation and management of various thrombotic disorders, replacing the 2008 edition. The details of the new guidelines can be found here

  • Pulmonary Hypertension after PE – CTEPH

    Pulmonary hypertension affects up to 4 % of PE patient and typically occurs within the first 2 years after a PE.  It is defined as a mean pulmonary artery pressure of ≥ 25 mm Hg by right heart catheterization, with normal pulmonary capillary wedge pressure, and elevated pulmonary vascular resistance.  Pulmonary hypertension occurring after an…