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Stephan Moll, MD writes (last updated: Sept 9th, 2020)… Background: Hospitalized patients with COVID-19 are at increased risk for thrombosis – DVT, PE, and may be pulmonary micro-vascular thrombosis that possibly contributes to respiratory failure; arterial events appear to occur less commonly. Scientific/clinical data on prevalence of thrombosis, best prevention, and optimal therapy are limited.
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Patients not infrequently inquire about the benefit of “natural blood thinners”. Clot Connect has written a document for patients – available here – discussing the various herbs and dietary supplements that are often called “natural blood thinners”. The blog post discusses many items including garlic, gingko, chocolate, fish oil, vitamin D, vitamin E, etc. The
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Stephan Moll, MD writes… A new drug for the urgent reversal of warfarin was approved by the FDA today, April 29th, 2013 (announcement by the FDA is here), called Kcentra. The drug is derived from pooled plasma from healthy blood donors and contains the coagulation factors that are low in warfarin-treated patients, i.e. factors II, VII,
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Stephan Moll, MD writes… The decision how long to treat a patient with venous thromboembolism (VTE) with anticoagulants can often be made based on the patient’s history alone, i.e. the circumstances of the VTE event (provoked versus unprovoked). Often, no thrombophilia testing is needed. However, if one were to do thrombophilia testing, what is the
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Stephan Moll, MD writes… Occasionally, recurrent DVT or PE occur in spite of warfarin therapy, particularly in patients with (a) fluctuating and sub-therapeutic INRs, (b) lupus anticoagulant/ antiphospholipid antibody (APLA) syndrome or (c) cancer.
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Stephan Moll writes… 2012 has been a year with significant progress in the field of venous thromboembolism and anticoagulation. The three most noteworthy, clinically relevant developments were probably (a) the publication of the new ACCP (American College of Chest Physician) guidelines on antithrombotic therapy in February 2012; (b) The FDA-approval of rivaroxaban (Xarelto) in November 2012 for the acute
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Stephan Moll, MD writes… Apixaban (Eliquis®) is FDA-approved for the prevention of stroke and systemic arterial thromboembolism in patients with atrial fibrillation (Clot Connect discussion of the approval on Dec 28th, 2012 is here). Here is the management guideline for apixaban
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Stephan Moll, MD writes… Xarelto® is FDA approved for treatment of venous thromboembolism (VTE), prevention of VTE after hip and knee replacement surgery, and for atrial fibrillation. A number of practical management questions are encountered by physicians, pharmacists, and other health care professional taking care of patients on Xarelto®, such as (a) dosing in
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Stephan Moll, MD writes… Today (Dec 28th, 2012) the FDA approved apixaban for the prevention of stroke and systemic arterial thromboembolism in patients with atrial fibrillation, based on the ARISTOTLE study [ref 1]. The FDA press release is here.
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Stephan Moll, MD writes… Well, it is not clear whether it does. A clinically relevant study (ASPIRE study) was published this week (Nov 22nd,2012) in the N Engl J Med [ref 1]. In patients who had a previous unprovoked (= idiopathic) DVT or PE and who had completed standard length (often considered to be 3-6 months)
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Stephan Moll, MD writes… Today is a very exciting day for patients and health care professionals: the oral anticoagulant Xarelto® (rivaroxaban) was FDA approved today (Nov 2nd, 2012) for the use in patients with DVT and PE – for the acute treatment of DVT and PE, as well as for the secondary long-term prevention of
A Clearinghouse for Information about Blood Clots (DVT/)PE) and Clotting Disorders (thrombophilia) provided as a public service by the University of North Carolina Blood Research Center
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