A Clearinghouse for Information about Blood Clots (DVT/)PE) and Clotting Disorders (thrombophilia) provided as a public service by the University of North Carolina Blood Research Center

Tag: factor V Leiden

  • Blood or Organ Donation: The Patient on Anticoagulants or with Thrombophillia

    A patient may ask:  “I am on warfarin – can I donate blood?”  Your answer:  “No”.  A person on an anticoagulant will not be accepted as a blood donor

  • Blood or Organ Donation: Being on Blood Thinners or Having a Thrombophilia

     “I am on warfarin (Coumadin®).  Can I donate blood?”  No.  A person on a blood thinner (anticoagulant), like warfarin, will not be accepted as a blood donor

  • Thrombophilia and Insurance

    Liz Varga, Certified Genetic Counselor, Nationwide Children’s Hospital, Columbus OH writes…. Some patients or their family members may be concerned about genetic testing for thrombophilias for fear of genetic discrimination.  Fortunately in the United States, laws are in place that can alleviate this concern. 

  • Thrombophilia and Insurance

    Liz Varga, Certified Genetic Counselor, Nationwide Children’s Hospital, Columbus OH writes…. Some people may have concerns about genetic testing for clotting disorders (thrombophilias) for fear of genetic discrimination.  Fortunately in the United States, we have laws in place that can alleviate this concern.

  • Pregnancy Loss and Clotting Disorders

    How common is pregnancy loss? What are the causes? Pregnancy loss (= miscarriage) in the general population is common. Most losses occur in the first trimester. As many as 5 % of women have 2 or more early losses; 1-2 % have 3 or more early losses [ref 1]. Well established risk factors for pregnancy…

  • Family Member Testing for Thrombophilia

    Background If a thrombophilia (clotting disorder) has been identified in a patient with blood clots (venous thromboembolism = VTE), the question arises whether other family members should be tested for the same thrombophilia. My Clinical Approach My approach in clinical practice to thrombophilia testing in family members is summarized in table 1:  Testing of Family Members.

  • Thrombophilia Testing – Who Should be Tested?

    Background and Consensus Guidelines No general consensus exists as to which patients with blood clots and which family members should be tested for thrombophilias.  At least five guidelines or consensus statements exist (ref 1-5).  They vary markedly in their recommendations as to who should be tested and who not,

  • Unexplained Arterial Clots – Causes, Thrombophilia Testing

    Background, anatomy Arteries are the blood vessels that lead blood away from the heart into the periphery, i.e. to the extremities, the brain, the abdominal and pelvic organs. They deliver oxygen to organs and muscles. Veins lead the blood back to the heart, from where it flows into the lung to take up fresh oxygen.…