A Clearinghouse for Information about Blood Clots (DVT/)PE) and Clotting Disorders (thrombophilia) provided as a public service by the University of North Carolina Blood Research Center

Tag: PE

  • Xarelto (Rivaroxaban) – Hospital Guideline

    Stephan Moll, MD writes… Xarelto® is FDA approved for treatment of venous thromboembolism (VTE), prevention of VTE after hip and knee replacement  surgery, and for atrial fibrillation.   A number of practical management questions are encountered by physicians, pharmacists, and other health care professional taking care of patients on Xarelto®, such as (a) dosing in…

  • Does Aspirin Prevent Recurrent DVT and PE? – ASPIRE Trial

    Stephan Moll, MD writes… Well, it is not clear whether it does.  A clinically relevant study (ASPIRE study) was published this week (Nov 22nd,2012) in the N Engl J Med  [ref 1].  In patients who had a previous unprovoked (= idiopathic) DVT or PE and who had completed standard length (often considered to be 3-6 months)…

  • Klippel-Trenaunay Syndrome, DVT and PE

    Stephan Moll, MD writes…  Klippel-Trenaunay Syndrome (KTS) is a rare congenital disorder of capillary, venous and lymphatic malformations and a localized disturbed growth of bone and/or soft tissue (see photographs)[ref 1].  Patients with KTS are at significantly increased risk for DVT, PE and superficial thrombophlebitis.  KTS affects only one side of the body, typically the leg or the…

  • Aspirin Prevents Recurrent DVT and PE – WARFASA Study

    Stephan Moll, MD writes… A clinically very relevant study (WARFASA) published today (May 24, 2012) in the New England Journal of Medicine [ref 1] shows that aspirin, 100 mg per day, reduces the risk of recurrent venous thromboembolism (VTE) in patients with unprovoked (= idiopathic) VTE, who have completed 6 to 18 months of anticoagulant therapy, without…

  • Rivaroxaban (Xarelto) and PE

    Stephan Moll, MD writes… Good news: The large phase 3 clinical trial comparing 3-12 months treatment of Rivaroxaban (Xarelto) with warfarin in patients with newly diagnosed pulmonary embolism was published on 3-26-2012 in the New England Journal of Medicine [reference 1], showing that Rivaroxaban was (a) noninferior to warfarin in its efficacy, (b) caused the…

  • Psychological impact of DVT and PE

    Beth Waldron, Program Director of Clot Connect, writes… The patient diagnosed with VTE (venous thromboembolism) may develop depression and anxiety, particularly if the clot was extensive and life-threatening.  However, evaluation of the care and outcome of patients with VTE is often focused upon the visible short-term effects of a clot, such as:  Has the acute clotting…

  • New ACCP Guidelines – DVT and PE: Highlights and Summary

    Stephan Moll, MD writes…  This month the American College of Chest Physicians (ACCP) published its new (2012) guidelines regarding anticoagulation and management of various thrombotic disorders, replacing the 2008 edition. The details of the new guidelines can be found here

  • Xarelto and DVT – Approved in Europe

    Xarelto (Rivaroxaban) was approved in Europe today (Dec 19th, 2011) for patients with acute DVT. This is good news