A Clearinghouse for Information about Blood Clots (DVT/)PE) and Clotting Disorders (thrombophilia) provided as a public service by the University of North Carolina Blood Research Center

List of posts


  • Stephan Moll, MD writes (last updated: Sept 9th, 2020)… Background:  Hospitalized patients with COVID-19 are at increased risk for thrombosis – DVT, PE, and may be pulmonary micro-vascular thrombosis that possibly contributes to respiratory failure; arterial events appear to occur less commonly. Scientific/clinical data on prevalence of thrombosis, best prevention, and optimal therapy are limited.

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  • Acrocyanosis

    Case Presentation A 28-year-old woman presents with progressive painless reddish-purple discoloration of both feet over one year. Symptoms started one year prior when she noticed that the creases of her toes were somewhat more purplish discolored.

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  • Blue Feet (Acrocyanosis)

    A 34-year-old woman presents with worsening painless reddish-purple discoloration of both feet.  Symptoms started one year ago when she noticed that the creases of her toes were somewhat more purplish discolored.

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  • A patient may ask:  “I am on warfarin – can I donate blood?”  Your answer:  “No”.  A person on an anticoagulant will not be accepted as a blood donor

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  •  “I am on warfarin (Coumadin®).  Can I donate blood?”  No.  A person on a blood thinner (anticoagulant), like warfarin, will not be accepted as a blood donor

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  • Two main guidelines exist which many physicians go by to decide whether a particular patient should get DVT prophylaxis after hip or knee replacement surgery, what method (compression device, or drug) to use, and for how long to give prophylaxis.  (a) One is the ACCP guideline (American College of Chest Physicians), last published in June 2008 [ref

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  • Two main guidelines exist which many physicians go by to decide whether a particular patient should get DVT prophylaxis after hip or knee replacement surgery, what method (compression device, or pharmacologic agent) to use, and for how long to give prophylaxis.  (a) One is the ACCP guideline (American College of Chest Physicians), last published in June 2008

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  • It has long been known that estrogen-containing birth control preparations (pill, patch, ring) increase the risk for DVT and PE (venous thromboembolism = VTE).  This risk is partially due to the estrogen.  However, part of the risk is also due to the type of progestin in these preparations.

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  • Birth control pills, patches and rings typically contain an estrogen and a progestin component.  It has long been known that estrogen-containing birth control preparations (pill, patch, ring) increase the risk for blood clots (DVT, PE).  This risk is partially due to the estrogen.  However, part of the risk for clots is also due to the

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  • “Is the generic version of Arixtra as safe and effective as brand Arixtra?”  Answer: “Yes”. The FDA evaluated and approved generic fondaparinux made by Dr. Reddy’s Laboratories Ltd. on July 11, 2011

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  • “Is generic Arixtra as safe and effective as brand Arixtra?” a patient asks.  Answer: Yes. Generic fondaparinux made by Dr. Reddy’s Laboratories Ltd. was approved by the FDA on July 11, 2011

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